ARISTOTLE says “nyah nyah – nah nah nah” to warfarin

AristotleThe search for an alternative to the pain-in-the-### that is warfarin goes on. There are some promising candidates. The FDA approved dabigatran (Pradaxa™), a direct thrombin inhibitor, back in November of last year. It has its pros and cons. In short, it is more effective than warfarin in preventing stroke in patients with non-valvular atrial fibrillation and is 74% less likely to cause serious bleeding than warfarin. No monitoring needed, either. Rivaroxaban(Xarelto™) is hot on its heels. Yesterday, as reported on, Bristol-Myers Squibb reported that their new entry into the anti-coagulant quagmire, apixaban (Eliquis™), a factor Xa inhibitor, is “noninferior” to warfarin in preventing stroke in atrial fibrillation.

This is just a preliminary report and there is no real data to look at right now. If you happen to be in Paris (yes, France) on August 28th, you can catch a detailed report at the European society of Cardiology Congress. The press release goes on to report that not only is apixaban noninferior to warfarin, it is also superior to warfarin in both stroke prevention and bleeding risk. Noninferiority and superiority aren’t the same thing, apparently, and it’s kind of a big deal, or so it appears.

The ARISTOTLE trial (Apixaban for the Prevention of Stroke in Subjects with Atrial Fibrillation) – where do you get ARISTOTLE out of that? – enrolled over 18000 subjects at more than 1000 centers in 40 countries. The subjects received either twice per day apixaban or “dose-adjusted” warfarin. I’m assuming that means a dose of warfarin necessary to achieve an international normalized ratio (INR) of no less than 2.0.

Bristol-Meyers Squibb is working with Pfizer and the companies hope to have FDA approval by the end of this year. The drug is already approved in Europe, but for the prevention of deep vein thrombosis in adults after elective hip or knee arthroplasty rather than stroke prevention in atrial fibrillation.

Beyond recognizing that patients taking these new drugs are at risk for bleeding, the implications in rehabilitation are largely unknown. There is no antidote for these medications, and there is no readily available monitoring that will tell health care providers whether or not the drugs are working. If these drugs are taken, they work. But we know that most people don’t take their meds as prescribed, especially over the long term. We’ll have to wait and see on this one, and on rivaroxaban, and on dabigatran. Keep an eye out right here for more info in the future – once I know something, I’ll make sure you know it, too.

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3 Responses to ARISTOTLE says “nyah nyah – nah nah nah” to warfarin

  1. not having an antidote is a major concern for patients. It’s a detail often left out when patients take these drugs. The risks of internal bleeding with no direct way of stopping the bleeding. Hopefully in the future the antidote gets made for these new drugs. I get nervous thinking about all the people taking these new drugs who don’t even know about that major risk.

  2. Rudy says:

    First, the official name of the trial is, “Apixiban for Reduction In STroke and Other Thromboembolic Events in Atrial Fibrilation”… hence ARISTOTLE. The name to which you are referring, is the NEJM’s abbreviated version. Second, the monitoring of these drugs is not necessary but they do have dose-proportional effects on prolonging the PTT, which can be measured. One of the benefits of these studies is that they prove that these drugs DO WORK and that they do so without having to be monitored like Warfarin. There are plenty of other drugs that patients take that don’t have laboratory assays associated with them and that we don’t monitor, but we either know or assume that they work. We don’t monitor serotonin levels in patients on SSRIs or biomarkers in patients on opioids. Third, “non-inferiority” and “superiority” are two VERY different things. In order for a drug to be deemed “non-inferior” it just needs to be powered enough to determine one-sided t-tests with p-values indicating that their study drug isn’t worse than the comparator. In order to be “superior” the trial has to have more rigorous design allowing for a two-sided t-test to assess for non-inferiority AND be able to tell if the study drug is actually better than the comparator drug. A drug that is non-inferior to another without any additional benefits (e.g. lower cost, easier dosing frequency, or better route of administration) will be less likely to gain FDA approval and will never gain a place in clinical practice.

    • pharminpt says:

      Thanks for the correction on the full name of the trial. I’ve often wondered if there is some sort of marketing team whose job it is to derive some sort of catchy acronym for a cardiovascular drug trial. I agree with you on all counts, my point is simply that, given the potential outcomes at both ends of the therapeutic spectrum – embolism and bleeding, and the comfort (at least for prescribing providers, and to some extent rehab professionals) of routine monitoring of INR with warfarin, this is a big change. As you’ve said, most drugs are not associated with monitoring via laboratory assays (good thing, probably) but, in my opinion, non-prescribing health care providers (i.e., physical therapists like me) should pay special attention to drugs that are – these are often drugs with narrow therapeutic windows. Patients and physicians could both use a break when it comes to warfarin – hopefully this turns out to be it.

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